Running on a lefty pitcher is one of the toughest tasks for a baserunner. There are many aspects to studying a lefty pitcher. Here I will focus on a fine point.
We know that a lefty pitcher must follow the 45 degree rule. Once the pitcher has committed to the plate (determined by his right leg having traveled 45 degrees from the line connecting his left leg and 1st base) he no longer is allowed to throw to 1st base.
Conservative baserunners will wait until a lefty pitcher has made this commitment to the plate. Be wary of an exception to the rule. If a pitcher's right leg crosses his left, he has committed himself to the plate. In this instance, a baserunner can often get a great jump on a lefty.
Stress the importance of studying a lefty's move. Players should do this on the bench so they are best prepared when they are in a live situation on first base.